Spanish giants confirm that the Argentinean will be out for six to eight weeks due to the hamstring injury suffered against Real Betis on Sunday.
Barcelona forward Lionel Messi is set to be sidelined for up to two months with a hamstring injury he sustained during Sunday's match with Real Betis.
Messi limped off after 21 minutes of the 4-1 win after injuring his left hamstring and he underwent further tests on Monday to determine the extent of the problem.
After receiving the results of those tests, Barcelona said the Argentinian is likely to be absent for between "six and eight weeks".
A Barca statement read: "According to the club's medical services, the tests taken on Monday morning by Leo Messi have confirmed that the player has suffered a torn muscle in the femoral biceps of his left leg.
"The approximate time he will be out is between six and eight weeks.
"The first part of his recovery will take place in Barcelona and the second, in Buenos Aires."
The injury will rule Messi out of both of Argentina's upcoming friendlies against Ecuador and Bosnia-Herzegovina as well as up to eight matches for Barca.
If he is not available again before the end of the year, Messi would sit out four La Liga matches, the Champions League clashes against Ajax and Celtic, and both legs of the Copa del Rey last-32 tie against Cartagena.
The good news for Barca is that they boast a three-point lead at the top of La Liga and are already through to the knockout stages in Europe.